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Programme

Friday, 28 November

13:00	Registration
14:00-14:15	Welcome addresses
	Session 1: Stem cell and cancer stem cells Chair: Gabriella Minchiotti
14:15-14:45	Keynote Lecture Enza Lonardo (Barcelona, Spain) TGF-beta signaling in Metastatic Stem Cells
14:45-15:00	Michela Lupia (Milan) Ovarian cancer stem cells: characterization and potential clinical use
15:00-15:15	Silvia Restelli (Milan) Regulatory mechanisms implicated in the control of Numb asymmetric partitioning in normal mammary stem cells
15:15-15:30	Cristina D'Aniello (Naples) A novel autoregulatory loop between L-Proline metabolism and the Gcn2-Atf4 stress pathway controls the embryonic stem cell-to-mesenchymal-like transition
15:30-15:45	Marta Peretti (Milan) Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma cancer stem cells, via inhibition of CLIC1-mediated ion current
15:45-16:00	Coffee Break
	Session 2: From cancer medicine to cell biology Chair: Alberto Bardelli
16:00-16:30	Keynote Lecture Alberto Bardelli (Turin) From cancer medicine to cell biology
16:30-16:45	Federica Fusella (Turin) Morgana: a novel player in apoptosis resistance and metastasis progression in breast tumorigenesis
16:45-17:00	Caterina Ieranò (Naples) CXCR4 cyclic peptide antagonist (PepR) – conjugated liposomes (PL–PepR): efficacy and specificity improvement
17:00-17:15	Antonino Colanzi (Naples) JNK2 phosphorylates GRASP65 to control fragmentation of the Golgi complex and G2/M transition in normal and cancer cells
17:15-17:30	Miriam Martini (Turin) Loss of PI3KC2A promotes tumorigenesis and aneuploidy in breast cancer
17:30-19:45	Poster Session
20:00	Dinner

Saturday, 29 November

	Session 3: Cell metabolism/autophagy in normal and cancer cells Chair: Francesco Cecconi
8:30-9:00	Keynote Lecture Francesco Cecconi (Rome/Copenhagen, Denmark) The autophagy signaling network in the coordination of a cell's response
9:00-9:15	Monica Nanni (Rome) HPV16 E5 deregulates autophagy in human keratinocytes
9:15-9:30	Martina Chiu (Parma) L-Asparaginase impairs the growth of liver cancer xenografts
9:30-9:45	Thomas Vaccari (Milan) Multiple functions of the SNARE protein Snap29 in autophagy and trafficking during epithelial formation in Drosophila
9:45-10:00	Giulia Santinon (Padua) Identification of a novel feedback mechanism linking aerobic glycolysis to oncogenic transcription
10:00-11:30	Poster Session & Coffee Break
	Session 4: Migration and invasion from cell model systems to human cancer Chair: Giorgio Scita
11:30-11:45	Veronica Astro (Milan) Elucidating the mechanisms of ERC1a/liprin-α1 complex mediated cell polarization and migration
11:45-12:00	Matteo Biancospino (Milan) Myosin VI bridges ubiquitin signaling and cell migration
12:00-12:15	Chiara Recchi (London, UK) The tumour suppressor protein OPCML prevents Axl-mediated EMT and motility in ovarian cancer cells
12:15-12:30	Gema Malet-Engra (Milan) Collective chemotaxis of malignant B cells
12:30-13:00	Keynote Lecture Philippe Chavrier (Paris, France) Mechanism of matrix metalloproteinase secretion during breast tumor cell invasion
13:00	Lunch

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